ProDots Recombinant Human IL-1beta/IL-1F2 (5 ug)
货号: PRD201-01 品牌: R&D Systems 库存: 国外现货
规格: 5ug
产品说明书
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价格: ¥ 4027.00

目录价: ¥4027.00

数量
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概述
简介
Supplied as ready-to-use 5 ug protein balls
别名
catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1B; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta
全称
Interleukin 1 beta
是否允许进口
允许
是否危险品
非危险品
性能
供应商
R&D Systems
Entrez Gene IDs
3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
内毒素水平
<0.10 EU per 1 μg of the protein by the LAL method.
生物活性
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED50 for this effect is typically <12 pg/mL.
溶解方法
For a stock solution, reconstitute at 25 μg/mL in sterile PBS, or simply roll ProDot
背景
IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.
Accession #
N-terminal
Sequence Analysis
Ala117 & Pro118
预期分子量
17 kDa
存放说明
4C
纯度
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
参考文献
  • Cancer Biomarkers
  • Chronic IL-1 beta-induced Neuroinflammation Is it Really that Bad?
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • ICC / IHC Images: IL-1 beta/IL-1F2
  • IL-1 Family
  • Infectious Diseases
  • Inflammasomes: Intracellular Regulators of Pathogen
  • Inflammatory Mediators
  • Interactive Pathway: IL-1 Family Signaling Pathways
  • Isolation, Culture, and Identification of Natural Killer Cells
  • LTi Cells
  • Macrophage Activation Markers
  • Mini-review: Interleukin 1
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • NCR-ILC3
  • Neuroinflammation
  • NOD-like Receptors and the Inflammasome
  • Platelets
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th9 Cells

参考图片

ProDots® Recombinant Human IL-1 beta /IL-1F2 stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED50 for this effect is typically 12 pg/mL.

1 μg/lane of ProDots® Recombinant Human IL-1 beta /IL-1F2 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing a single band at 17 kDa.

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