促销 γ-Catenin Antibody
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货号: 2309S 品牌: CST 反应种属:
Human/Mouse/Rat/Hamster/Monkey
Human/Mouse/Rat/Hamster/Monkey
应用:
W/IP/IHC-P/IF-IC
W/IP/IHC-P/IF-IC
规格: 100ul
产品说明书
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价格: ¥ 3600.00

目录价: ¥3600.00

数量
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概述
反应种属
Human/Mouse/Rat/Hamster/Monkey
来源宿主
Rabbit
应用
W/IP/IHC-P/IF-IC
目标/特异性
γ-Catenin Antibody detects endogenous levels ot total γ-catenin protein. The antibody does not cross-react with β-catenin.
使用方法
WB(1:1000) IP (1:100) IHC-P (1:50) IF-IC (1:400)
是否允许进口
允许
是否危险品
非危险品
性能
供应商
CST
灵敏度
Endogenous
背景

Also known as plakoglobin, γ-catenin is a member of the Armadillo family of signaling molecules, which includes β-catenin and the Drosophila protein armadillo (1). This family of proteins is involved in Wnt signaling, which is important in embryonic development and in tumorigenesis (2-3). Although the two vertebrate proteins β- and γ-catenin display sequence homology, γ-catenin likely plays a role distinct from that of β-catenin (1, 4-6). γ-catenin localizes to desmosomes and adherens junctions, both sites of intercellular adhesion, and interacts with the cytoplasmic domains of classical and desmosomal cadherins. Interaction of γ- or β-catenin with α-catenin, desmoplakin and other junction proteins provides a link between intercellular junctions and the actin and intermediate filament cytoskeleton. Maintenance and/or modification of this link is vital for control of cell adhesion and migration (1). γ-catenin is modified by phosphorylation, affecting both adhesion and β-catenin dependent transcription (7), and by and O-glycosylation, affecting adhesion (8). Recent evidence suggests that γ-catenin regulates desmosomal adhesion in response to growth factor stimulation (9).

存放说明
-20C
计算分子量
83

参考图片

Western blot analysis of extracts from 293, MCF-7 and C2C12 cells using γ-Catenin Antibody.使用γ-Catenin抗体对293, MCF-7和C2C12细胞提取物进行western blot分析。

Immunohistochemical analysis of paraffin-embedded human breast carcioma using gamma-Catenin Antibody.使用gamma-Catenin抗体对石蜡包埋的人乳腺癌组织进行免疫组化分析。

Immunohistochemical analysis of paraffin-embedded human lung carcinoma using gamma-Catenin Antibody.使用gamma-Catenin抗体对石蜡包埋的人肺癌组织进行免疫组化分析。

Immunohistochemical analysis of paraffin-embedded human colon carcioma using gamma-Catenin Antibody.使用gamma-Catenin抗体对石蜡包埋的人结肠癌组织进行免疫组化分析。

Confocal immunofluorescent analysis of HT-29 cells labeled with gamma-Catenin Antibody (green). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).使用gamma-Catenin抗体(绿色)对HT-29细胞进行激光共聚焦免疫荧光分析。蓝色假色=DRAQ5™(DNA荧光染料)。

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