ProDots Recombinant Human IL-6 Protein (5 ug)
货号: PRD206-01 品牌: R&D Systems 反应种属:
Human
Human
库存: 国外现货
规格: 5ug
产品说明书
分享:

价格: ¥ 1468.00

目录价: ¥1468.00

数量
- +
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概述
简介
Supplied as ready-to-use 5 ug protein balls
别名
B cell stimulatory factor-2; B-cell differentiation factor; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFN-beta 2; IFN-beta-2; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A
全称
Interleukin 6
反应种属
Human
是否允许进口
允许
是否危险品
非危险品
性能
供应商
R&D Systems
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
内毒素水平
<0.10 EU per 1 μg of the protein by the LAL method.
生物活性
Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813.

The ED50 for this effect is typically 0.2-0.8 ng/mL.

背景
IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.
Accession #
N-terminal
Sequence Analysis
Pro29
预期分子量
20.3 kDa
SDS-PAGE
21 kDa, reducing conditions
存放说明
4C
纯度
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
参考文献
  • Adipocytokines
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • Diabetes
  • gamma delta T Cells
  • Glucose Homeostasis
  • Helper T (Th) Cells
  • HIF Transcription Factors
  • ICC / IHC Images: IL-6
  • IL-6 Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Interactive Pathway: Adipocytokines & Insulin Signaling
  • Interactive Pathway: Th17 Differentiation
  • Macrophage Activation Markers
  • Mini-review: Interleukin 6
  • Mouse Obesity Antibody Array
  • Multiple Myeloma
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Neuroinflammation
  • Obesity
  • Plasmacytoid Dendritic Cells
  • Role of IL-6 in Energy Expenditure
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th22 Cells
  • Th9 Cells

参考图片

1 μg/lane of ProDots® Recombinant Human IL-6 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized with silver staining, showing a single band at 21 and 20 kDa, respectively.

ProDots® Recombinant Human IL-6 stimulates cell proliferation of the T1165.85.2.1 mouse plasmacytoma cell line.The ED50 for this effect is typically 0.2-0.8 ng/mL.

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