GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) induces the development of monocytes, neutrophils, eosinophils, and myeloid and dermal dendritic cells. It also acts as a neutrophil and dendritic cell chemoattractant. GM-CSF promotes Th1 and Th17 cell mediated autoimmune inflammation as well as the inflammatory activation of dendritic cells, microglia, alveolar macrophages, and eosinophils. In addition, it cooperates with G-CSF in promoting tumor cell proliferation and invasion. GM-CSF signals through a receptor complex composed of GM-CSF R alpha and the Common beta Chain (beta c) with Syndecan-2 as a potential co-receptor. The beta c subunit is shared by the receptor complexes for IL-3 and IL-5.
- Common beta Chain Receptor Family
- Cytokines and Receptors in Allergy and Asthma
- Cytokines and Receptors in Angiogenesis
- Dendritic Cell Development
- Gametes and Fertilization
- gamma delta T Cells
- ICC / IHC Images: GM-CSF
- Inflammatory Mediators
- Isolation, Culture, and Identification of Natural Killer Cells
- Macrophage Activation Markers
- Myeloid-derived Suppressor Cells (MDSC)
- Natural Killer T (NKT) Cells
- T Cell Cytokine Signaling
1 μg/lane of ProDots® Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized with silver staining, showing a single band at approximately 14 kDa.
ProDots Recombinant Human GM-CSF stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is typically 6-30 pg/mL