ProDots Recombinant Human GM-CSF Protein (5 ug)-ProDots蛋白-蛋白-优宁维蛋白&多肽平台
ProDots Recombinant Human GM-CSF Protein (5 ug)
货号: PRD215-01 品牌: R&D Systems 反应种属:
Human
Human
库存: 公司缺货
规格: 5ug
产品说明书
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价格: ¥ 1468.00

目录价: ¥1468.00

数量
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概述
简介
Supplied as ready-to-use 5 ug protein balls
别名
colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; CSF2; GM-CSF; GMCSFgranulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897; molgramostin; sargramostim
全称
Granulocyte Macrophage Growth Factor
反应种属
Human
是否允许进口
允许
是否危险品
非危险品
性能
供应商
R&D Systems
Entrez Gene IDs
1437 (Human); 12981 (Mouse); 116630 (Rat); 397208 (Porcine); 403923 (Canine); 493805 (Feline)
内毒素水平
<0.10 EU per 1 μg of the protein by the LAL method.
生物活性
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is typically 6-30 pg/mL.
溶解方法
Add ProDot directly to the medium or reconstitute in the vial at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
背景

GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) induces the development of monocytes, neutrophils, eosinophils, and myeloid and dermal dendritic cells. It also acts as a neutrophil and dendritic cell chemoattractant. GM-CSF promotes Th1 and Th17 cell mediated autoimmune inflammation as well as the inflammatory activation of dendritic cells, microglia, alveolar macrophages, and eosinophils. In addition, it cooperates with G-CSF in promoting tumor cell proliferation and invasion. GM-CSF signals through a receptor complex composed of GM-CSF R alpha and the Common beta Chain (beta c) with Syndecan-2 as a potential co-receptor. The beta c subunit is shared by the receptor complexes for IL-3 and IL-5.

Accession #
N-terminal
Sequence Analysis
Ala18
预期分子量
14 kDa
SDS-PAGE
14 kDa, reducing conditions
存放说明
4C
纯度
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
参考文献
  • Common beta Chain Receptor Family
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Dendritic Cell Development
  • Gametes and Fertilization
  • gamma delta T Cells
  • ICC / IHC Images: GM-CSF
  • Inflammatory Mediators
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Macrophage Activation Markers
  • Myeloid-derived Suppressor Cells (MDSC)
  • Natural Killer T (NKT) Cells
  • T Cell Cytokine Signaling

参考图片

1 μg/lane of ProDots® Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized with silver staining, showing a single band at approximately 14 kDa.

ProDots Recombinant Human GM-CSF stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is typically 6-30 pg/mL

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