ProDots Recombinant Human IFN-gamma Protein (5 ug)
货号: PRD285-01 品牌: R&D Systems 反应种属:
Human
Human
库存: 国外现货
规格: 5ug
产品说明书
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价格: ¥ 660.00

目录价: ¥660.00

数量
- +
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概述
简介
Supplied as ready-to-use 5 ug protein balls
别名
IFG; IFI; IFNG; IFN-gamma; Immune interferon; interferon gamma; interferon, gamma
全称
Interferon gamma
反应种属
Human
是否允许进口
允许
是否危险品
非危险品
性能
供应商
R&D Systems
Entrez Gene IDs
3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)
内毒素水平
<0.10 EU per 1 μg of the protein by the LAL method.
生物活性
Measured in anti-viral assays using HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. Meager, A. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 129. The ED50 for this effect is typically 0.15-0.75 ng/mL.
溶解方法
Add ProDot directly to the medium or reconstitute in the vial at 200 μg/mL in sterile deionized water
背景
IFN-gamma (Interferon-gamma) is the prototype proinflammatory cytokine and is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. IFN-gamma dimers signal through a receptor complex of two IFN-gamma R1 and two IFN-gamma R2 subunits.
Accession #
N-terminal
Sequence Analysis
Met
预期分子量
16.9 kDa
SDS-PAGE
17 kDa, reducing conditions
存放说明
4C
纯度
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
参考文献
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • Group 1 ILCs
  • ICC / IHC Images: IFN-gamma
  • IL-10/Interferon Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Interactive Pathway: Th1 Differentiation
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Macrophage Activation Markers
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Natural Killer T (NKT) Cells
  • NCR+ILC3
  • NCR-ILC3
  • Neuroinflammation
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th1 Cells

参考图片

1 μg/lane of ProDots® Recombinant Human IFN-gamma was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized with silver staining, showing a single band at 17 kDa.

ProDots® Recombinant Human IFN-gamma demonstrates anti-viral activity in HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. The ED50 for this effect is typically 0.15-0.75 ng/mL.

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