ProDots Recombinant Human IGF-I/IGF-1 Protein (5 ug)-ProDots蛋白-蛋白-优宁维蛋白&多肽平台
ProDots Recombinant Human IGF-I/IGF-1 Protein (5 ug)
货号: PRD291-01 品牌: R&D Systems 反应种属:
Human
Human
库存: 公司缺货
规格: 5ug
产品说明书
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价格: ¥ 660.00

目录价: ¥660.00

数量
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概述
简介
Supplied as ready-to-use 5 ug protein balls
别名
IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C
全称
Insulin-like Growth Factor I
反应种属
Human
是否允许进口
允许
是否危险品
非危险品
性能
供应商
R&D Systems
Entrez Gene IDs
3479 (Human); 16000 (Mouse); 24482 (Rat)
内毒素水平
<0.10 EU per 1 μg of the protein by the LAL method.
生物活性
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is typically 0.3-1.5 ng/mL.
溶解方法
Add ProDot directly to the medium or reconstitute at 200 μg/mL in sterile PBS.
背景

Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.

The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.

Accession #
N-terminal
Sequence Analysis
Gly49
预期分子量
7.6 kDa
SDS-PAGE
7 kDa, reducing conditions
存放说明
4C
纯度
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
参考文献
  • ALS Related Molecules
  • Cancer Biomarkers
  • Cytokines in Lipid/Cholesterol Metabolism
  • Diabetes and Obesity Research
  • gamma delta T Cells
  • Glucose Homeostasis
  • ICC / IHC Images: IGF-I
  • IGF Family
  • IGF Ligands
  • IGF-II, Developmental Abnormalities and Genomic Imprinting
  • Insulin-like Growth Factor (IGF) and Receptors
  • Insulin-Like Growth Factors and Cancer
  • Mouse Obesity Antibody Array
  • Preeclampsia
  • Protein/Peptide Hormones and Regulators
  • Reproduction

参考图片

1 μg/lane of ProDots® Recombinant Human IGF-I was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing a single band at 7 kDa. 

ProDots® Recombinant Human IGF-I stimulates proliferation in the MCF-7 human breast cancer cell line. The ED50 for this effect is typically 0.3-1.5 ng/mL.

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