Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.
The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.
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- Cytokines in Lipid/Cholesterol Metabolism
- Diabetes and Obesity Research
- gamma delta T Cells
- Glucose Homeostasis
- ICC / IHC Images: IGF-I
- IGF Family
- IGF Ligands
- IGF-II, Developmental Abnormalities and Genomic Imprinting
- Insulin-like Growth Factor (IGF) and Receptors
- Insulin-Like Growth Factors and Cancer
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- Protein/Peptide Hormones and Regulators
1 μg/lane of ProDots® Recombinant Human IGF-I was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing a single band at 7 kDa.
ProDots® Recombinant Human IGF-I stimulates proliferation in the MCF-7 human breast cancer cell line. The ED50 for this effect is typically 0.3-1.5 ng/mL.