Caspase-1/ICE Inhibitor Z-WEHD-FMK (1 mg)-Annexin V & Caspase系列检测-凋亡检测-优宁维单/多因子检测试剂盒平台
Caspase-1/ICE Inhibitor Z-WEHD-FMK (1 mg)
货号: FMK002 品牌: R&D Systems 库存: 公司缺货
规格: 1mg

价格: ¥ 3634.00

目录价: ¥3634.00

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CASP1; CASP-1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta; caspase-1; EC 3.4.22; EC; ICE; ICEP45; IL-1 beta-converting enzyme; IL1BC CASP1 nirs variant 1; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1-B converting enzyme; interleukin 1-beta convertase; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
R&D Systems
Entrez Gene IDs
834 (Human)
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Spleen Tyrosine Kinase (Syk) Mediates IL-1beta Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.
Authors: Callaway J, Smith S, McKinnon K, de Silva A, Crowe J, Ting J
J Biol Chem, 2015;290(28):17306-20.
Species: Human
Sample Type: Whole Cells

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
PLoS ONE, 2015;10(8):e0136708.
Species: Human
Sample Type: Whole Cells

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
Authors: Gonzalez-Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, Dube P, Bergman M, Orihuela C
PLoS Pathog, 2015;11(12):e1005337.
Species: Mouse
Sample Type: Whole Cells

The flagellar regulator TviA reduces pyroptosis by Salmonella enterica serovar Typhi.
Authors: Winter S, Winter M, Atluri V, Poon V, Romao E, Tsolis R, Baumler A
Infect Immun, 2015;83(4):1546-55.
Species: Mouse
Sample Type: Whole Cells

Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin.
Authors: Xia M, Boini K, Abais J, Xu M, Zhang Y, Li P
Am J Pathol, 2014;184(5):1617-28.
Species: Mouse
Sample Type: Whole Cells

Bacillus anthracis capsule activates caspase-1 and induces interleukin-1beta release from differentiated THP-1 and human monocyte-derived dendritic cells.
Authors: Cho MH, Ahn HJ, Ha HJ, Park J, Chun JH, Kim BS, Oh HB, Rhie GE
Infect. Immun., 2010;78(1):387-92.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Active caspase-1-mediated secretion of retinoic acid inducible gene-I.
Authors: Kim, Min-Jung, Yoo, Joo-Yeon
J Immunol, 2008;181(10):7324-31.
Species: Human
Sample Type: whole cells
Application: Bioassay
Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection.
Authors: Jin H, Xiao C, Zhao G, Du X, Yu Y, Kang Y, Wang B
J. Cell. Biochem., 2007;102(4):980-91.
Species: Mouse
Sample Type: Cell Lysates

RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
Blood, 2004;103(11):4180-7.
Species: Human
Sample Type: Whole Cells


Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

  • Apoptosis: Caspase Pathways
  • Apoptosis: Mitochondria Accused of Murder
  • Caspases and Regulators
  • Cysteine Proteases and Regulators
  • ICC / IHC Images: Caspase-1
  • Inflammasomes: Intracellular Regulators of Pathogen
  • Interactive Pathway: Apoptosis Signaling Pathways
  • Mini-review: Caspases
  • NOD-like Receptors and the Inflammasome
  • Novel Caspase-8 Roles Revealed by Knockouts
  • Technical Notes: Caspase Antibodies
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