N-dodecanoyl-L-Homoserine lactone- 基因调控试剂- 分子生物学-优宁维生化试剂平台
N-dodecanoyl-L-Homoserine lactone
货号: abs47045015-10mg 品牌: Absin 库存: 公司缺货
规格: 10mg
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价格: ¥ 1756.00

目录价: ¥1756.00

数量
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概述
描述
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-dodecanoyl-L-Homoserine lactone (C 12-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. 1,2,3 In addition to regulating bacterial functions, C 12-HSL activates NF-κB in RAW 264.7 macrophages, increasing the expression of TNF-α, interleukin-1β (IL-1β), and IL-8, while other lactones do not. 4 In addition, C 12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. 5 It is important to note that C 12-HSL is distinct from N-3-oxo-dodecanoyl-L-Homoserine lactone (Catalog No. 10007895), which is produced at different times in biofilm development 6 and has different cellular effects. 5
别名
C12-HSL;dDHL;
是否允许进口
允许
是否危险品
非危险品
性能
供应商
Absin
存放说明
Store at -20℃
纯度
≥98%
计算分子量
283.4
CAS号
137173-46-7
参考文献
1.Kuo, A.,Blough, N.V. and Dunlap, P.V. Multiple N-acyl-L-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri. Journal of Bacteriology 176(24), 7558-7565 (1994).
2.Lithgow, J.K.,Wilkinson, A.,Hardman, A., et al. The regulatory locus cinRI in Rhizobium leguminosarum controls a network of quorum-sensing loci. Molecular Microbiology 37(1), 81-97 (2000).
3.McClean, K.H.,Winson, M.K.,Fish, L., et al. Quorum-sensing and Chromobacterium violaceum: Exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones. Microbiology 143, 3703-3711 (1997).
4.Gomi, K.,Kikuchi, T.,Tokue, Y., et al. Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer. Infection and Immunity 74(12), 7029-7031 (2006).
5.Kristiansen, S.,Bjarnsholt, T.,Adeltoft, D., et al. The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the putrescine synthesis in human cells. Acta Pathologica, Microbiologica, et Immunologica Scandinavica 116, 361-371 (2008).
6.Huang, Y.L.,Ki, J.S.,Lee, O.O., et al. Evidence for the dynamics of acyl homoserine lactone and AHL-producing bacteria during subtidal biofilm formation. ISME Journal 1-9 (2008).
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