NF-Kpa B p65 (pS529) Alexa 488 50Tst-Phosflow磷酸化蛋白流式检测抗体-PhosFlow-优宁维流式&磁珠分选平台
NF-Kpa B p65 (pS529) Alexa 488 50Tst
货号: 558421 品牌: BD Pharmingen 同种亚型:
Mouse BALB/c IgG2b, κ
Mouse BALB/c IgG2b, κ
反应种属:
Human (QC Testing) 
Human (QC Testing) 
应用:
Intracellular staining (flow cytometry) (Routinely Tested) 
Intracellular staining (flow cytometry) (Routinely Tested) 
库存: 公司缺货
规格: 50Tst
产品说明书
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价格: ¥ 3760.00

目录价: ¥3760.00

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概述
描述
Nuclear factor k B (NF- k B) is a ubiquitously expressed transcription factor that regulates the expression of 200-300 genes. It is crucial for basic cellular responses to stress and pathogens, such as proliferation, survival, development, and apoptosis. The most studied NF- k B complex consists of the p50 (also known as NF- k B1) and p65 (also known as REL-A) subunits, both containing a 300-amino acid region with homology to the Rel proto-oncogene product (RH domain). The RH domain contains motifs for dimerization, nuclear localization, and binding to specific DNA sequences. In addition to the RH domain, the p65 subunit contains the transactivation domain, which is responsible for the interaction with the inhibitor I k B and which contains phosphorylation sites. In most cell types, the p50/p65 heterodimer is located within the cytoplasm complexed to I k B. This complex prevents nuclear translocation and activity of NF- k B. In response to stimuli such as cytokines, LPS, DNA damage, and viral infections, I k B is phosphorylated at critical residues. This phosphorylation induces dissociation of the I k B/NF- k B complex, allowing the free heterodimeric NF- k B to translocate to the nucleus. Furthermore, optimal activation of NF- k B requires phosphorylation in the transactivation domain of p65. In the nucleus, activated NF- k B dimers bind to the k B sites within promoters and enhancers and function as transcriptional activators.

The K10-895.12.50 monoclonal antibody recognizes the phosphorylated serine 529 (pS529) in the transactivation domain of human NF- k B p65 subunit.

别名
transcription factor p65, RELA, MGC131774, NFKB3
同种亚型
Mouse BALB/c IgG2b, κ
反应种属
Human (QC Testing) 
来源宿主
Mouse
应用
Intracellular staining (flow cytometry) (Routinely Tested) 
形式

Format:Alexa Fluor® 488
Excitation Source:Blue 488 nm
Excitation Max:495 nm
Emission Max:519 nm
使用方法
IC/FC
Vol. Per Test
20 µl
是否允许进口
允许
是否危险品
非危险品
性能
供应商
BD Pharmingen
免疫原
Phosphorylated Human NF-κB p65 Peptide
标记(有特殊处理)
Alexa Fluor® 488 荧光素亮度 查看
存放说明
冷藏2-8℃
存储溶液
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
产品用途
RUO

参考图片

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